Current Position
Professor/Director, Institute of Traditional Medicine, NYCU
Director, Traditional Chinese Medicine Glycomics Research Center
Professor/Associate Chair, School of Chinese Medicine, NYCU
Adjunct Professor, Biomedical Industry Ph.D. Program, NYCU
Adjunct Professor, Program in Molecule Medicine, NYCU
Office
9F, Traditional Medicine Building
6F, Shou-Ren Building
Specialty
1. 癌症生物學 (Cancer Biology)
2. 蛋白質降解 (Protein Degradation Pathways)
3. 訊息傳遞 (Signal Transduction)
Research Interests
中草藥萃取物開發並探討中草藥抗癌生長與轉移之功能與機制
(The functions and mechanisms of herbal medicine suppressed cancer progression and metastasis)
1. 真菌類小分子蛋白質
(Fungal immunomodulation proteins (FIPs) from Ganoderma)
2. 真菌類與海洋藻類之硫化多醣體
(Sulfated polysaccharides from medical fungi and marine organisms)
3. 中藥複方
(Chinese medicine formula)
Selected Publications
Publications:
Papers
1. Zhi-Hu Lin, Sang-Nguyen-Cao Phan, Diem-Ngoc-Hong Tran, Mei-Kuang Lu, Tung-Yi Lin*. Anti-inflammatory and anti-cancer effects of polysaccharides from Antrodia cinnamomea: A review. Journal of the Chinese Medical Association. 2024. In press. (SCI, IF: 1.9, Rank: 32.0%) Corresponding author
2. Zhi-Hu Lin, Hung-Chih Lo, Chia-Chuan Chang, Mei-Kuang Lu*, Ai-Jung Tseng, Chi-Hsein Chao, Chi-Hong Chao, Tung-Yi Lin*. Sulfated polysaccharide from Antrodia cinnamomea mycelium cultured with zinc sulfate stimulates M1 polarization of macrophages through AKT/mTOR pathways. International Journal of Biological Macromolecules. 2024. 279: 135548. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
3. Hung-Chih Lo, Tzu-En Lin, Che-Yu Lin, Wei-Hao Wang, Yu-Chen Chen, Pei-Hsien Tsai, Jung-Chen Su, Mei-Kuang Lu, Wei-Hung Hsu, Tung-Yi Lin*. Targeting TGFβ receptor-mediated snail and twist: WSG, a polysaccharide from Ganoderma lucidum, and it-based dissolvable microneedle patch suppress melanoma cells. Carbohydrate Polymers. 2024. 341:122298. (SCI, IF: 10.7, Rank: 1.7%) Corresponding author
4. Chung-Ting Kao, Fan-Wei Yang, Meng-Chen Wu, Tzu-Huan Hung, Chen-Wei Hu, Chiu-Hua Chen, Pin-Chien Liou, Te-Lun Mai, Chia-Chih Chang, Tung-Yi Lin, Ying-Lan Chen*, Ying-Chung Jimmy Lin*, Jung-Chen Su*. Systematic synthesis and identification of monolignol pathway metabolites. New Phytologist. 2024. 244(4):1143-1167. (SCI, IF: 8.3, Rank: 4.2%)
5. Wei-Jyun Hua, Wei-Lun Hwang, Hsin Yeh, Zhi-Hu Lin, Wei-Hung Hsu, Tung-Yi Lin*. Ganoderma microsporum immunomodulatory protein combined with KRASG12C inhibitor impedes intracellular AKT/ERK network to suppress lung cancer cells with KRAS mutation. International Journal of Biological Macromolecules. 2024. 259:129291. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
6. Hung-Chih Lo, Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Li-Chen Huang, Yi-Ru Ciou, Runcheng Ruan, Kai-Fan Lin, Ai-Jung Tseng, Alexander T.H. Wu, Wei-Hung Hsu, Chi-Hong Chao, Tung-Yi Lin*. GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer. Life Sciences. 2023. 335: 122255. (SCI, IF:5.2, Rank: 11.3%) Corresponding author
7. Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Ai-Jung Tseng, Li-Chen Huang, Wei-Lun Qiu, Tsung-Hsi Tu, Ding-Han Wang, Wei-Hung Hsu, Wei-Lun Hwang, Tung-Yi Lin*. Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells. Cancer Letters. 2023. 578: 216458. (SCI, IF: 9.1, Rank: 10.2%) Corresponding author
8. Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Ling Yang, Tung-Yi Lin, Muh-Hwa Yang, Tung-Hu Tsai*. Transporter modulation of molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-brain barrier in a rat. Communications medicine. 2023. 3: 150. (SCI, IF: 5.4, Rank: 19.0%)
9. Chueh-Tan Chen, Chian-Feng Chen, Tung-Yi Lin, Wei-Jyun Hua, Kate Hua, Ching-Yao Tsai*, Chung-Hua Hsu*. Traditional Chinese medicine Kuan-Sin-Yin decoction inhibits cell mobility via downregulation of CCL2, CEACAM1 and PIK3R3 in hepatocellular carcinoma cells. Journal of Ethnopharmacology. 2023. 317:114636. (SCI, IF: 4.8, Rank: 9.3%) Third author
10. Wei-Lun Qiu, Hung-Chih Lo, Mei-Kuang Lu, Tung-Yi Lin*. Significance of culture period on the physiochemistry and anti-cancer potentials of polysaccharides from mycelia of Ganoderma lucidum. International Journal of Biological Macromolecules. 2023. 242:125181. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
11. Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai*. Transfer and biotransformation of the COVID-19 prodrug molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-placenta barrier. eBioMedicine. 2023. 95: 104748. (SCI, IF: 9.7, Rank: 6.3%)
12. Yong-Hong Yang, Che-Sheng Wen, Yung-Ling Kuo, Su-Ling Fu, Tung-Yi Lin, Chao-Ming Chen, Po-Kuei Wu, Wei-Ming Chen, Jir-You Wang. GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes releases and delays aging in the MSC senescence process. Journal of Ethnopharmacology. 2023. 317: 116784. (SCI, IF: 4.8, Rank: 9.3%)
13. Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai*. Biotransformation and brain distribution of the anti-COVID-19 drug molnupiravir and herb-drug pharmacokinetic interactions between the herbal extract Scutellaria formula-NRICM101. Journal of Pharmaceutical and Biomedical Analysis. 2023. 234:115499. (SCI, IF: 3.1, Rank: 34.9%)
14. Zhi-Hu Lin, Hsin Yeh, Hung-Chih Lo, Wei-Jyun Hua, Ming-Yang Ni, Li-Kai Wang, Ting-Ting Chang, Muh-Hwa Yang, Tung-Yi Lin*. GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway. International Journal of Biological Macromolecules. 2023. 241: 124648. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
15. Zhi-Hu Lin, Mei-Kuang Lu, Hung-Chih Lo, Chia-Chuan Chang, Ai-Jung Tseng, Chi-Hsein Chao, Tung-Yi Lin*. ZnF3, a sulfated polysaccharide from Antrodia cinnamomea, inhibits lung cancer cells via induction of apoptosis and activation of M1-like macrophage-induced cell death. International Journal of Biological Macromolecules. 2023. 238:124144. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
16. Tung-Yi Lin*, Hung-Chih Lo, Wei-Lun Qiu, Chi-Hsein Chao, Mei-Kuang Lu, and Hsien-Yeh Hsu. Biochemical characterization and anti-cancer activity of tangential flow filtration system assisted purification of fucoglucan from Laminaria japonica. International Journal of Biological Macromolecules. 2023. 227:1-9. (SCI, IF: 7.7, Rank: 6.4%) First & Corresponding author
17. Ai-Jung Tseng, Tsung-Hsi Tu, Wei-Jyun Hua, Hsin Yeh, Ching-Jung Chen, Zhi-Hu Lin, Wei-Hung Hsu, Ying-Lan Chen, Chuan-Chih Hsu, Tung-Yi Lin*. GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells. International Journal of Biological Macromolecules. 2022. 219:940-948. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
18. Yi-Hong Lin, Chih-Ning Tsai, Po-Feng Chen, Yen-Tzu Lin, Sorour Darvishi, Hubert H. Girault, Tung-Yi Lin, Mei-Yi Liao, and Tzu-En Lin*. AI-Assisted Fusion of Scanning Electrochemical Microscopy Images Using Novel Soft Probe. ACS Measurement Science Au. 2022. 6:576-583. (SCI, IF: 4.6, Rank: 19.8%)
19. Tzu-En Lin*, Ming-Chun Chien, Po-Feng Chen, Pei-Wen Yang, Huai-En Chang, Ding-Han Wang, Tung-Yi Lin, and Yung-Jung Hsu. A Sensor-Integrated Face Mask Using Au@SnO2 Nanoparticle Modified Fibers and Augmented Reality Technology. ACS Omega. 2022. 7:42233-42241. (SCI, IF: 3.7, Rank: 36.5%)
20. Leonel Pereira, Chia-Chuan Chang, Jianxun Ding, Tung-Yi Lin and Zhong Liu. The polysaccharides from marine organisms and fungi: Biological functions and molecular mechanisms. Frontiers in Pharmacology. 2022. 13:1085346. (SCI, IF: 4.4, Rank: 18.4%)
21. Ha Phan Thanh Ho, Di Ngoc KhaVo, Tung-Yi Lin, Jo-Ning Hung, Ya-Hui Chiu, Ming-Han Tsai*. Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion. Biomedicine & Pharmacotherapy. 2022. 155:113766. (SCI, IF: 6.9, Rank: 4.2%) Third author
22. Hsin Yeh, Di Ngoc Kha Vo, Zhi-Hu Lin, Ha Phan Thanh Ho, Wei-Jyun Hua, Wei-Lun Qiu, Ming-Han Tsai, Tung-Yi Lin*. GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus. Phytomedicine. 2022. 103: 154215. (SCI, IF: 6.7, Rank: 4.7%) Corresponding author
23. Yueh-Hsin Ping, Hsin Yeh, Li-Wei Chu, Zhi-Hu Lin, Yin-Chieh Hsu, Lie-Chwen Lin, Chung-Hua Hsu, Shu-Ling Fu, Tung-Yi Lin*. The Traditional Chinese Medicine Formula Jing Guan Fang for preventing SARS-CoV-2 infection: from clinical observation to basic research. Frontiers in Pharmacology. 2022. 13:744439. (SCI, IF: 4.4, Rank: 18.4%) Corresponding author
24. Yun-Tsung Chen, Yao-Yi Hsieh, Jen-Yu Ho, Chien Chang Ho, Tung-Yi Lin* and Jung-Charng Lin. Running interval training combined with blood flow restriction increases maximal running performance and muscular fitness in male runners. Scientific reports. 2022. 12:9922. (SCI, IF: 3.8, Rank: 18.7%) Corresponding author
25. Kai-Wei Chang, Tung-Yi Lin, Shu-Ling Fu, Yueh-Hsin Ping, Fen-Pey Chen, Yen-Ying Kun*. A Houttuynia Cordata-based Chinese herbal formula improved symptoms of allergic rhinitis during COVID-19 pandemic. Journal of the Chinese Medical Association. 2022. 85(6):717-722. (SCI, IF: 1.9, Rank: 32.0%) Second author
26. Yun-Tsung Chen, Yao-Yi Hsieh, Jen-Yu Ho, Tung-Yi Lin* and Jung-Charng Lin. Two weeks of detraining reduces cardiopulmonary function and muscular fitness in endurance athletes. European journal of sport science. 2022. 22(3):399-406. (SCI, IF: 2.4, Rank: 28.3%) Corresponding author
27. Yun-Tsung Chen, Yao-Yi Hsieh, Jen-Yu Ho, Tung-Yi Lin, and Jung-Charng Lin. Running training combined with blood flow restriction increases cardiopulmonary function and muscle strength in endurance athletes. Journal of strength and conditioning research. 2022. 36(5):1228-1237. (SCI, IF: 2.5, Rank: 26.0%)
28. Zhi-Hu Lin, Jinsong Hu, Huagang Shi, Chia-Ching Liaw, Wei-Lun Qiu, Wei-Hung Hsu, Tung-Yi Lin*. Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression. Journal of Ethnopharmacology. 2022. 282:114636. (SCI, IF: 4.8, Rank: 9.3%) Corresponding author
29. Wei-Lun Qiu, Wei-Hung Hsu, Shu-Ming Tsao, Ai-Jung Tseng, Zhi-Hu Lin, Wei-Jyun Hua, Hsin Yeh, Tzu-En Lin, Chien-Chang Chen, Li-Sheng Chen, Tung-Yi Lin*. WSG, a glucose-rich polysaccharide from Ganoderma lucidum, combined with cisplatin potentiates inhibition of lung cancer in vitro and in vivo. Polymers. 2021. 13(24):4353. (SCI, IF: 4.7, Rank: 19.1%) Corresponding author
30. Wei-Hung Hsu, Wei-Jyun Hua, Wei-Lun Qiu, Ai-Jung Tseng, Hsin-Chung Cheng, Tung-Yi Lin*. WSG, a glucose-enriched polysaccharide from Ganoderma lucidum, suppresses tongue cancer cells via inhibition of EGFR-mediated signaling and potentiates cisplatin-induced apoptosis. International Journal of Biological Macromolecules. 2021. 193:1201-1208. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
31. Tung-Yi Lin*, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng. Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells. Phytomedicine. 2021. 80:153384. (SCI, IF: 6.7, Rank: 4.7%) First & Corresponding author
32. Wei-Shan Hsu, Anant Preet, Tung-Yi Lin and Tzu-En Lin*. Miniaturized Salinity Gradient Energy Harvesting Devices. Molecules. 2021. 26(18): 5469. (SCI, IF: 4.2, Rank: 28.1%) Third author
33. Wei-Hung Hsu, Wei-Lun Qiu, Shu-Ming Tsao, Ai-Jung Tseng, Mei-Kuang Lu, Wei-Jyun Hua, Hsin-Chung Cheng, Hsien-Yeh Hsu, Tung-Yi Lin*. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer. International Journal of Biological Macromolecules. 2020. 165:1604-1613. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
34. Tung-Yi Lin*, Mei-Kuang Lu, Ai-Jung Tseng, Chi-Hsein Chao. Effects of sterol-type elicitors on biochemical characterization of polysaccharides from Antrodia cinnamomea. International Journal of Biological Macromolecules. 2020. 162:1476-1483. (SCI, IF: 7.7, Rank: 6.4%) First & Corresponding author
35. Tung-Yi Lin, Mei-Kuang Lu, Chia-Chuan Chang*. Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signaling. International Journal of Biological Macromolecules. 2020. 157:311-318. (SCI, IF: 7.7, Rank: 6.4%) First author
36. Wei-Lun Qiu, Ai-Jung Tseng, Hsien-Yeh Hsu, Wei-Hung Hsu, Zhi-Hu Lin, Wei-Jyun Hua, Tung-Yi Lin*. Fucoidan increased the sensitivity to gefitinib in lung cancer cells correlates with reduction of TGFβ-mediated Slug expression. International Journal of Biological Macromolecules. 2020. 153:796-805. (SCI, IF: 7.7, Rank: 6.4%) Corresponding author
