Faculty

Faculty

Chen, Ying-Chou / 陳瀅州

Department of Life Sciences / Institute of Genome Sciences

 02-2826-7230
 
 yjoechen@nycu.edu.tw

Current Position
Assistant Professor, Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University

 

Office
Tradition Medicine Building A, Room 107

 

Academic Degrees
Ph.D., Genetics, Michigan State University

 

Experience
2013-2017 Synthetic Biology Center, Massachusetts Institute of Technology, USA.
2007-2013 Van Andel Research Institute, USA.
2009 Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.

 

Specialty
Synthetic biology, high-throughput genetic screens, CRISPR/Cas technology, and genetic models of human diseases.

 

Research Interests
Development of high-throughput and integrative screening platforms.
Probing and modulating the complex networks in neurological and metabolic disorders.

 

Selected Publications


  • Randomized CRISPR-Cas transcriptional perturbation screening reveals novel protective genes against alpha-synuclein toxicity. Molecular Cell, 68:247-257, 2017.
  • DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae. Genetics, 194(2):389-401, 2013.
  • Dbf4 regulates the Cdc5 polo-like kinase through a distinct non-canonical binding interaction. J Biol Chem., 31;285(53):41244-54, 2010.
  • Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase. PLoS Genet. 5(5):e1000498, 2009.