National Yang Ming Chiao Tung University

Faculty

Faculty

Kao, Cheng-Yen / 高正彥

Institute of Microbiology & Immunology

 02-2826-7112 (Office)
 
 kaocy@nycu.edu.tw;kaocy64@gmail.com

Current Position

Assistant professor, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan


Education

2009/9 ~ 2014/7- Ph.D., Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.

2005/9 ~ 2007/7- M.S., Institute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan.

2001/9 ~ 2005/7- B.S., Department of Biochemical Science and Technology, National Chia Yi University, Chiayi, Taiwan.

 
Professional Experience

2019/8 ~ present- Assistant professor, Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan.

2017/10 ~ 2019/7- Postdoctoral fellow, Department of Medical Microbiology and Immunology, University of Wisconsin-Madison (Dr. John-Demian (JD) Sauer Lab).

2016/8 ~ 2017/10- Postdoctoral fellow, Department of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan (Prof. Jiunn-Jong Wu Lab).

2014/8 ~ 2016/7- Postdoctoral fellow, Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan (Prof. Jiunn-Jong Wu Lab).

2009/9 ~ 2014/7- Lecturer, Gole educational institution. 高元文教機構.


Teaching courses

Microbiology and Immunology, Biotechnology, Molecular Biology.

 

Research Interest & Expertise

Antimicrobial resistance mechanisms, Bacterial genomics and NGS, Virulence factors and bacterial pathogenesis, Gene regulation and transcriptome, Mouse model for bacterial infection, Antimicrobial-drug development.

 

Lab website

https://sites.google.com/view/kaolab/home?authuser=0

 

Memberships

European Society of Clinical Microbiology and Infectious Diseases (Member ID: 134433, 2017 ~).

American Society for Microbiology (Member ID: 57016792/43426372, 2012 ~).

Taiwan Society of Microbiology (Member ID: S93, 2010 ~).

Taiwan Testing and Quality Assurance Society (TTQAS) (2019 ~)

 

Peer-Reviewed Research Articles (2012 ~) (Citation: Google Scholar Database)

  • Virulence factors & Pathogenesis
  • The glycosyltransferase Jhp0106 (PseE) is involved in flagellin glycosylation and motility in Helicobacter pylori.
  • Yang KY*, Kao CY*, Su SW Marcia*, Chen YL, Wang S, Chen JW, Teng CH, Hu ST, Wu JJ. (*equal contribution).
  • J Biomed Sci. 2020. (In revision).(SCI, IF: 5.762, 5-Year IF: 4.724, Ranking: 17/138 Medicine, Research, & Experimental)
  • Mutation of the transcriptional regulator YtoI rescues Listeria monocytogenes mutants deficient in the essential shared metabolite 1,4-dihydroxy-2-naphthoate (DHNA).
  • Chen GY*, Kao CY*, Smith H, Rust D, Zach P, Li AY, Sauer JD. (*equal contribution).
  • Infect Immun. 2019 Nov 4. pii: IAI.00366-19. doi: 10.1128/IAI.00366-19.(SCI, IF: 3.201, 5-Year IF: 3.401, Ranking: 39/93 Infectious disease)
  • Inactivation of ferric uptake regulator (Fur) attenuates Helicobacter pylori J99 motility by disturbing the flagellar motor switch and autoinducer-2 production.
  • Lee AY*, Kao CY*, Wang YK, Lin SY, Lai TY, Sheu BS, Lo CJ, Wu JJ. (*equal contribution).
  • Helicobacter. 2017 Aug;22(4). doi: 10.1111/hel.12388. Epub 2017 Apr 12.(SCI, IF: 4.000, 5-Year IF: 3.536, Ranking: 40/135 Microbiology) (Citation: 7)
  • The Helicobacter pylori J99 jhp0106 gene, under the Control of the CsrA/RpoN Regulatory System, Modulates Flagella Formation and Motility.
  • Kao CY, Chen JW, Wang S, Sheu BS, Wu JJ.
  • Front Microbiol. 2017 Mar 28;8:483. doi: 10.3389/fmicb.2017.00483. eCollection 2017.(SCI, IF: 4.235, 5-Year IF: 4.926, Ranking: 34/135 Microbiology) (Citation: 3)
  • Intracellular Osteopontin Induced by CagA-positive Helicobacter pylori Promotes Beta-catenin Accumulation and Interleukin-8 Secretion in Gastric Epithelial cells.
  • Chang WL, Yang HB, Cheng HC, Yeh YC, Kao CY, Wu JJ, Lu CC, Sheu BS.
  • Helicobacter. 2015 Dec;20(6):476-84. doi: 10.1111/hel.12225. Epub 2015 Mar 3.
  • (SCI, IF: 4.000, 5-Year IF: 3.536, Ranking: 40/135 Microbiology) (Citation: 7)
  • Genome Sequence and Annotation of Helicobacter pylori Strain Hp238 Isolated from a Taiwanese Patient with MALT Lymphoma.
  • Kao CY, Chen JW, Huang YT, Sheu SM, Sheu BS, Wu JJ.
  • Genome Announc. 2015 Feb 19;3(1). pii: e00006-15. doi: 10.1128/genomeA.00006-15. (Citation: 2)
  • CsrA regulates Helicobacter pylori J99 motility and adhesion by controlling flagella formation.
  • Kao CY, Sheu BS, Wu JJ.
  • Helicobacter. 2014 Dec;19(6):443-54. doi: 10.1111/hel.12148.(SCI, IF: 4.000, 5-Year IF: 3.536, Ranking: 40/135 Microbiology) (Citation: 21)
  • The Complex Interplay among Bacterial Motility and Virulence Factors in Different Escherichia coli Infections.
  • Kao CY, Lin WH, Tseng CC, Wu AB, Cheng SW, Wang MC, Wu JJ.
  • Eur J Clin Microbiol Infect Dis. 2014 Dec;33(12):2157-62. doi: 10.1007/s10096-014-2171-2.
  • (SCI, IF: 2.837, 5-Year IF: 2.914, Ranking: 45/93 Infectious Diseases) (Citation: 18)
  • Higher glucose level can enhance the H. pylori adhesion and virulence related with type IV secretion system in AGS cells.
  • Sheu SM, Cheng H, Kao CY, Yang YJ, Wu JJ, Sheu BS.
  • J Biomed Sci. 2014 Oct 9;21(1):96. doi:10.1186/s12929-014-0096-9.(SCI, IF: 5.762, 5-Year IF: 4.724, Ranking: 17/138 Medicine, Research, & Experimental) (Citation: 9)
  • Higher motility enhances bacterial density and inflammatory response in dyspeptic patients infected with Helicobacter pylori.
  • Kao CY, Sheu BS, Sheu SM, Yang HB, Chang WL, Cheng HC, Wu JJ.
  • Helicobacter. 2012 Dec;17(6):411-6. doi: 10.1111/j.1523-5378.2012.00974.x.
  • (SCI, IF: 4.000, 5-Year IF: 3.536, Ranking: 40/135 Microbiology) (Citation: 29)
  • Length of thymidine homopolymeric repeats modulates promoter activity of sabA in Helicobacter pylori.
  • Kao CY, Sheu SM, Sheu BS, Wu JJ.
  • Helicobacter. 2012 Jun;17(3):203-9. doi: 10.1111/j.1523-5378.2012.00936.x.(SCI, IF: 4.000, 5-Year IF: 3.536, Ranking: 40/135 Microbiology) (Citation: 20)
  • H. pylori clinical isolates have diverse babAB genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes.
  • Sheu SM, Sheu BS, Chiang WC, Kao CY, Wu HM, Yang HB, Wu JJ.
  • BMC Microbiol. 2012 May 30;12:89. doi: 10.1186/1471-2180-12-89.
  • (SCI, IF: 2.989, 5-Year IF: 3.381, Ranking: 67/135 Microbiology) (Citation: 19)
  • Antibiotic resistance and mechanisms
  • Identification of novel OmpC variants contribute to carbapenem and cefepime resistance in Escherichia coli.
  • Chen LH, Kao CY, Yan JJ, Wu JJ.
  • J. Clin. Micro. 2020. (In preparation).
  • (SCI, IF: 5.897, 5-Year IF: 4.663, Ranking: 20/135 Microbiology)
  •  Evaluation of Modified Carbapenem Inactivation Method (mCIM) and EDTA-CIM (eCIM) for Phenotypic Detection of Carbapenemase-Producing Enterobacteriaceae.
  • Tsai YM, Wang S, Chiu HC, Kao CY*, Wen LL*. (*equal contribution).
  • BMC Microbiol. 2020. (Under review).
  • (SCI, IF: 2.989, 5-Year IF: 3.381, Ranking: 67/135 Microbiology)
  •  Characterization of CRISPR-Cas systems in Clinical Klebsiella pneumoniae Isolates Uncovers its Potential Association with Antibiotic Susceptibility.
  • Li HY*, Kao CY*, Lin WH, Zheng PX, Yan JJ, Wang MC, Teng CH, Wu JJ. (*equal contribution).
  • Front Microbiol. 2018 Jul. doi: 10.3389/fmicb.2018.01595.
  • (SCI, IF: 4.235, 5-Year IF: 4.926, Ranking: 34/135 Microbiology) (Citation: 11)
  •  Comparative Genomics of Escherichia coli Sequence Type 219 Clones from the Same Patient: Evolution of the IncI1 blaCMY-Carrying Plasmid in Vivo.
  • Kao CY, Chen JW, Liu TL, Yan JJ, Wu JJ.
  • Front Microbiol. 2018 Jul. doi: 10.3389/fmicb.2018.01518.
  • (SCI, IF: 4.235, 5-Year IF: 4.926, Ranking: 34/135 Microbiology) (Citation: 4)
  • Molecular Characterization of Antimicrobial Susceptibility of Salmonella Isolates: First Identification of a Plasmid Carrying qnrD or oqxAB in Taiwan.
  • Kao CY*, Chen CA*, Liu YF, Wu HM, Chiou CS, Yan JJ, Wu JJ. (*equal contribution)
  • J Microbiol Immunol Infect. 2017 Apr;50(2):214-223. doi: 10.1016/j.jmii.2015.03.004. Epub 2015 May 14.(SCI, IF: 3.493, 5-Year IF: 2.745, Ranking: 48/135 Microbiology) (Citation: 25)
  • Complete Genome Sequence of Carbapenem-Resistant Klebsiella pneumoniae Strain 1756, Isolated from a Pus Specimen.
  • Kao CY, Yan JJ, Lin YC, Zheng PX, Wu JJ.
  • Genome Announc. 2017 Mar 30;5(13). pii: e00066-17. doi: 10.1128/genomeA.00066-17.(Citation: 2)
  • Molecular characterization of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp. isolates in Mongolia.
  • Kao CY, Udval U, Huang YT, Wu HM, Huang AH, Bolormaa E, Yan JJ, Urangoo Z, Batbaatar G, Khosbayar T, Wu JJ.
  • J Microbiol Immunol Infect. 2016 Oct;49(5):692-700. doi: 10.1016/j.jmii.2015.05.009. (SCI, IF: 3.493, 5-Year IF: 2.745, Ranking: 48/135 Microbiology) (Citation: 14)
  • Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015.
  • Kao CY, Wu HM, Lin WH, Tseng CC, Yan JJ, Wang MC, Teng CH, Wu JJ.
  • Sci Rep. 2016 Aug 30;6:32281. doi: 10.1038/srep32281.(SCI, IF: 3.998, 5-Year IF: 4.576, Ranking: 17/71 Multidisciplinary Sciences) (Citation: 24)
  • Overproduction of active efflux pump and variations of OprD dominate in imipenem-resistant Pseudomonas aeruginosa isolated from patients with bloodstream infection in Taiwan.
  • Kao CY*, Chen SS*, Hung KH, Wu HM, Hsueh PR, Yan JJ, Wu JJ. (*equal contribution)
  • BMC Microbiol. 2016 Jun 13;16(1):107. doi: 10.1186/s12866-016-0719-2.(SCI, IF: 2.989, 5-Year IF: 3.381, Ranking: 67/135 Microbiology) (Citation: 18)
  • First characterization of fluoroquinolone resistance mechanisms in CTX-M-producing Escherichia coli from Mongolia.
  • Kao CY, Udval U, Wu HM, Bolormaa E, Yan JJ, Khosbayar T, Wu JJ.
  • Infect Genet Evol. 2016 Mar;38:79-81. doi:10.1016/j.meegid.2015.12.010.(SCI, IF: 2.773, 5-Year IF: 2.720, Ranking: 48/93 Infectious Diseases) (Citation: 2)
  •  Dissemination of OXA-Carbapenemase-Producing Acinetobacter baumannii ST195 and ST642 in a Mongolian Hospital.
  • Kao CY, Udval U, Oyunchimeg R, Wu HM, Huang AH, Bolormaa E, Munkhtuya E, Yan JJ, Batbaatar G, Khosbayar T, Wu JJ.
  • Infect Genet Evol. 2014 Dec;28:313-6. doi: 10.1016/j.meegid.2014.10.024. (SCI, IF: 2.773, 5-Year IF: 2.720, Ranking: 48/93 Infectious Diseases) (Citation: 5)
  • Clinical and microbiological characteristics of Klebsiella pneumonia from community-acquired recurrent urinary tract infections.
  • Lin WH, Kao CY, Yang DC, Tseng CC. Wu AB, Teng CH, Wang MC, Wu JJ.
  • Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1533-9. doi: 10.1007/s10096-014-2100-4.(SCI, IF: 2.837, 5-Year IF: 2.914, Ranking: 45/93 Infectious Diseases) (Citation: 27)
  • First Report of the Prevalence of Extended-Spectrum β-Lactamase Producing Escherichia coli in Two Mongolian Hospitals.
  • Kao CY*, Udval U*, Wu HM, Bolormaa E, Yan JJ, Khosbayar T, Wu JJ. (*equal contribution)
  • Infect Genet Evol. 2014 Jul;25:66-8. doi: 10.1016/j.meegid.2014.04.012.
  • (SCI, IF: 2.773, 5-Year IF: 2.720, Ranking: 48/93 Infectious Diseases) (Citation: 5)
  • Heteroresistance of Helicobacter pylori from the same patient prior to antibiotic treatment.
  • Kao CY, Lee AY, Huang AH, Song PI, Yang YJ, Sheu SM, Chang WL, Sheu BS, Wu JJ.
  • Infect Genet Evol. 2014 Apr;23:196-202. doi: 10.1016/j.meegid.2014.02.009.(SCI, IF: 2.773, 5-Year IF: 2.720, Ranking: 48/93 Infectious Diseases) (Citation: 33)
  • Gemifloxacin can partially overcome quinolone resistance of H. pylori with gyrA mutation in Taiwan.
  • Chang WL, Kao CY, Wu CT, Huang AH, Wu JJ, Yang HB, Cheng HC, Sheu BS.
  • Helicobacter. 2012 Jun;17(3):210-5. doi: 10.1111/j.1523-5378.2012.00935.x.(SCI, IF: 4.000, 5-Year IF: 3.536, Ranking: 40/135 Microbiology) (Citation: 25)


 
Applications of microbiology

  • Fermented soymilk and soy and cow milk mixture, supplemented with orange peel fiber or Tremella flava fermented powder as prebiotics for high EPS-producing Lactobacillus pentosus SLC 13.
  • Huang ML, Huang JY, Kao CY, Fang TJ.
  • J Sci Food Agric. 2019 Jul;99(9):4373-4382. doi: 10.1002/jsfa.9671. Epub 2019 Apr 9. (SCI, IF: 2.614, 5-Year IF: 2.945, Ranking: 8/58 Agriculture, Multidisciplinary) (Citation: 4)
  • Complete genome sequence of Lactobacillus pentosus SLC13, isolated from mustard pickles, a potential probiotic strain with antimicrobial activity against foodborne pathogenic microorganisms.
  • Huang ML, Huang JY, Kao CY, Fang TJ.
  • Gut Pathog. 2018 Jan 18;10:1. doi: 10.1186/s13099-018-0228-y. eCollection 2018.(SCI, IF: 3.274, 5-Year IF: 3.473, Ranking: 55/135 Microbiology) (Citation: 6)
  • Characterization of high exopolysaccharide-producing Lactobacillus strains isolated from mustard pickles for potential probiotic applications.
  • Huang JY, Kao CY, Liu WS, Fang TJ.
  • Int Microbiol. 2017 Jun;20(2):75-84. doi: 10.2436/20.1501.01.287.
  • (SCI, IF: 1.833, 5-Year IF: 1.803, Ranking: 105/135 Microbiology) (Citation: 7)
  • Orange Peel Fiber and Tremella flava Chen Fermented Powder Effectively Induce Exopolysaccharide Production by Lactobacillus plantarum SLC 13.
  • Huang JY, Huang ML, Kao CY, Fang TJ.
  • Int. J. Agric. Biol. 2017. 19(3):437-444. doi: 10.17957/IJAB/15.0298.(SCI, IF: 0.822, 5-Year IF: 0.906, Ranking: 38/58 Agriculture, Multidisciplinary) (Citation: 4)
  • An Integrated Microfluidic System for Diagnosis of the Resistance of Helicobacter pylori to Quinolone-Based Antibiotics.
  • Chao CY, Wang CH, Che YJ, Kao CY, Wu JJ, Lee GB.
  • Biosens Bioelectron. 2016 Apr 15;78:281-9. doi: 10.1016/j.bios.2015.11.046.
  • (SCI, IF: 10.257, 5-Year IF: 8.669, Ranking: 1/86 Chemistry, Analytical) (Citation: 17)


Review Papers

  • A battlefield between host and bacteria in the cytosol.
  • Kao CY, Zach P, Sauer JD.
  • PLoS Pathog. 2019. (In preparation).(SCI, IF: 6.218, 5-Year IF: 6.479, Ranking: 19/135 Microbiology)
  •  Defeating antibiotic-resistant bacteria: exploring alternative drug targets for a post-antibiotic era.
  • Wang CH, Hsieh YH, Zach P, Kao CY.
  • Int J Mol Sci. 2020 Feb 5;21(3). pii: E1061. doi: 10.3390/ijms21031061.(SCI, IF: 4.556, 5-Year IF: 4.653, Ranking: 74/297 Biochemistry & Molecular biology) (Citation: 3)
  • Helicobacter pylori Infection: An Overview of Bacterial Virulence Factors and Pathogenesis.
  • Kao CY, Sheu BS, Wu JJ.
  • Biomed J. 2016 Feb;39(1):14-23. doi: 10.1016/j.bj.2015.06.002. Epub 2016 Apr 1.(SCI, IF: 3.697, 5-Year IF: N/A, Ranking: 114/297 Biochemistry & Molecular biology) (Citation: 187)
  • The Challenge of Fluoroquinolone Resistance: Epidemiology, Mechanisms, and Clinical impact.
  • Kao CY, Wu JJ.
  • J Biomed Lab Sci. 台灣生檢雜誌.2015 Sep;27(3):77-86.
  • Carbapenem Resistance: Epidemiology, Mechanisms and Screening Methods.
  • Kao CY, Wu JJ.
  • J Biomed Lab Sci. 台灣生檢雜誌. 2015 Mar;27(1):1-9.

Conference Papers

Evaluation of Modified Carbapenem Inactivation Method (mCIM) and EDTA-CIM (eCIM) for Phenotypic Detection of Carbapenemase-Producing Enterobacteriaceae.

Wang S, Tsai YM, Chiu HC, Kao CY, Wen LL. 

陽明大學108學年度學術論文研討會National Yang-Ming University 2020 Annual Academic Poster Seminar (June 11th, National Yang-Ming University)
 
Characterization of carbapenem-resistant Acinetobacter isolated from patients with bacteremia in a university hospital in Taiwan, 1997-2015
Lei CH, Lee YT, Wu JJ, Kao CY.
陽明大學108學年度學術論文研討會National Yang-Ming University 2020 Annual Academic Poster Seminar (June 11th, National Yang-Ming University)
 
High prevalence of B2-ST95 and B2-ST131 among Escherichia coli isolated from patients with recurrent urinary tract infections.
Zhang YZ, Lin WH, Lee YT, Teng CH, Wu JJ, Wang MC, Kao CY.
陽明大學108學年度學術論文研討會National Yang-Ming University 2020 Annual Academic Poster Seminar (June 11th, National Yang-Ming University)
 
Mutation of TrfA, a novel transcriptional regulator of fermentation, rescues cytosolic survival of 1,4-dihydroxy-2-naphthoate (DHNA) deficient Listeria monocytogenes
Kao CY, Chen GY, Smith H, Li AY, Rust D, Sauer JD. (2019, Poster).
119 美國微生物學會年會 American Society for Microbiology 2019 119th General Meeting (June 20th-24th, San Francisco).
 
Mutation of TrfA, a novel transcriptional regulator of fermentation, rescues cytosolic survival of 1,4-dihydroxy-2-naphthoate (DHNA) deficient Listeria monocytogenes
Kao CY, Chen GY, Smith H, Li AY, Rust D, Sauer JD. (2019, Poster).
10th Perlman Symposium on Antibiotic Discovery and Development, University of Wisconsin-Madison, WI (April 26th, Madison).
 
A novel screen suggests that regulation of fermentation is critical for cytosolic survival and virulence of Listeria monocytogenes.
Kao CY, Chen GY, Sauer JD. (2018, Poster)
25th Annual Midwest Microbial Pathogenesis Conference (MMPC), University of Iowa, Iowa, IA (Sep 28th-30th, Iowa).
 
Jhp0106, a novel flagella-associated protein involved in post-translational modification of FlaA in Helicobacter pylori.
Yang KY, Kao CY, Wang S, Sheu BS, Hu ST, Wu JJ. (2018, Poster)
European Helicobacter and Microbiota Study Group – EHMSG. XXXIst International Workshop on Helicobacter & Microbiota in Inflammation & Cancer (Sep 14th-15th, Kaunas, Lithuania).
 
A Novel Screen Suggests that Regulation of Fermentation is Critical for Cytosolic Survival and Virulence of Listeria monocytogenes.
Kao CY, Chen GY, Sauer JD. (2018, Oral & Poster)
118 美國微生物學會年會 American Society for Microbiology 2018 118th General Meeting (June 7th-11th, Atlanta).
 
Comparative genomics uncover in vivo evolution in multi-drug resistant Escherichia coli sequence type 219: Identification of IncI1-plasmid carrying blaCMY-111 to blaCMY-4 within-host.
Kao CY, Chen JW, Chen LH, Yan JJ, Wu JJ. (2018, Poster)
The 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (April 21st-24th, Madrid, Spain).
 
Association of CsrA alleles with variations in pathology of Helicobacter pylori.
Kao CY, Chang WL, Sheu BS, Yang HB, Wu JJ. (2017, Poster)
The 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (April 22nd-25th, Vienna, Austria).
 
Inactivation of Ferric Uptake Regulator (Fur) Attenuates Helicobacter pylori J99 Motility by Disturbing the Flagellar Motor Switch. (2017, Poster)
Lee AY, Kao CY, Lai TY, Sheu BS, Lo CJ, Wu JJ.
The 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (April 22nd-25th, Vienna, Austria).
 
Helicobacter pylori J99 jhp0106 Gene, Under the Control of CsrA/RpoN Regulatory System, Modulates Flagella Formation and Motility. (2016, Oral)
Kao CY, Chen JW, Wang S, Sheu BS, Wu JJ.
台灣微生物學會第二十二屆第一次會員大會及學術研討會. Taiwan Society of Microbiology 2016 annual meeting and symposium (Dec 10th-11th, Taipei, Taiwan).
 
Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015. (2016, Oral)
Kao CY, Wu HM, Lin WH, Tseng CC, Yan JJ, Wans MC, Teng CH, Wu JJ.
台灣微生物學會第二十二屆第一次會員大會及學術研討會. Taiwan Society of Microbiology 2016 annual meeting and symposium (Dec 10th-11th, Taipei, Taiwan).
 
Characterization of Exopolysaccharide-Producing Lactic Acid Bacteria Isolated from Mustard Pickles for Possible Probiotic Application. (2016, Oral)
Huang JY, Huang ML, Kao CY, Fang TJ
5th Asian Federation of Societies for Lactic Acid Bacteria International Symposium (Nov 28th-30th, Taipei, Taiwan).
 
Strain‐Specific Regulation of Flagella Genes in Helicobacter pylori: A Complex Interplay Between CsrA and RpoN. (2016, Poster)
Huang YT, Kao CY, Wu JJ.
116 美國微生物學會年會 American Society for Microbiology 2016 116th General Meeting. (June 16th-20th, Boston)
 
Genome Sequence and Annotation of Helicobacter pylori Strain Hp238 Isolated from a Taiwanese Patient with MALT Lymphoma. (2015, Poster).
Kao CY, Chen JW, Sheu BS, Wu JJ.
115 美國微生物學會年會American Society for Microbiology 2015 115th General Meeting (May 30th-June 2nd, New Orleans).
 
Characterization of Plasmids Encoding CTX-M β-Lactamase in Escherichia coli and Klebsiella spp. isolates in Mongolia. (2015, Poster).
Wu JJ, Kao CY, Khosbayar T.
115 美國微生物學會年會 American Society for Microbiology 2015 115th General Meeting (May 30th-June 2nd, New Orleans).
 
First report of the prevalence of antibiotic resistance in Mongolian hospitals: Focus on Escherichia coli and Acinetobacter baumannii. (2014, Oral).
Kao CY, Udval U, Oyunchimeg R, Bolormaa E, Munkhtuya E, Yan JJ, Batbaatar G, Khosbayar T, Wu JJ.
台灣微生物學會第二十一屆第二次會員大會及學術研討會. Taiwan Society of Microbiology 2014 annual meeting and symposium (Dec 13th-14th, Tainan, Taiwan).
 
Roles of Helicobacter pylori motility in pathogenesis and its regulatory mechanism: From clinical investigation to basic research. (2014, Oral).
Kao CY, Sheu BS, Wu JJ.
台灣微生物學會第二十一屆第二次會員大會及學術研討會. Taiwan Society of Microbiology 2014 annual meeting and symposium (Dec 13th-14th, Tainan, Taiwan).
 
Strain-specific of CsrA-regulatory system in controlling H. pylori motility. (2014, Poster).
Huang YT, Kao CY, Wu JJ.
台灣第十九屆細菌學研討會 (Aug 21st-23rd, Kaohsiung, Taiwan).
 
An Integrated Microfluidic System for Diagnosis of Quinolones Resistance of Helicobacter pylori (2014, Poster).
Chao CY, Wang CH, Che YJ, Kao CY, Wu JJ, Lee GB.
The 27th IEEE International Conference on Micro Electro Mechanical Systems (Jan 26th-28th, San Francisco).
 
Heteroresistance of Helicobacter pylori from the same patient prior to antibiotic treatment. (2013, Oral).
Kao CY, Lee AY, Huang AH, Song PY, Yang YJ, Sheu SM, Chang WL, Sheu BS, Wu JJ.
台灣微生物學會第二十一屆第一次會員大會及學術研討會. Taiwan Society of Microbiology 2013 annual meeting and symposium (Dec 14th-15th, Taipei, Taiwan).
 
Isolation of Helicobacter pylori with Different Antibiotic Susceptibility in a Single Patient (2013, Poster).
Kao CY, Lee AY, Huang AH, Song PY, Yang YJ, Sheu SM, Chang WL, Sheu BS, Wu JJ.
Gastro 2013 APDW/WCOG Shanghai (Sep 21st-24th, Shanghai, China).
 
CsrA Regulates H. pylori Motility and Adhesion through Controlling the Alternative Sigma Factor rpoN and Flagella Formation. (2013, Poster).
Kao CY, Sheu BS, Wu JJ.
113 美國微生物學會年會 American Society for Microbiology 2013 113th General Meeting (May 18th-21st, Denver).
 
CsrA regulates H. pylori motility and adhesion ability through controlling alternative sigma factor rpoN expression and flagella formation. (2012, Oral).
Kao CY, Sheu BS, Wu JJ.
台灣微生物學會第二十屆第三次會員大會及學術研討會. Taiwan Society of Microbiology 2012 annual meeting and symposium (Dec 15th-16th, Tainan, Taiwan).
 
Length of thymidine homopolymeric repeats modulates promoter activity of sabA in Helicobacter pylori. (2012, Poster).
Kao CY, Sheu SM, Sheu BS, Wu JJ.
112 美國微生物學會年會 American Society for Microbiology 2012 112th General Meeting (June 16th-19th, San Francisco).
 
Helicobacter pylori with Higher Motility Enhances Bacterial Density and Inflammatory Response in Dyspeptic Patients. (2012, Poster).
Kao CY, Sheu BS, Yang HB, Chang WL, Cheng HC, Wu JJ.
The 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (March 31st-April 2nd, London, United Kingdom).
 
CsrA regulates H. pylori motility and adhesion ability through controlling alternative sigma factor rpoN expression and flagella formation. (2011, Poster).
Kao CY, Sheu BS, Wu JJ.
2nd International Symposium on Infectious Disease and Signal Transduction. 第二屆傳染性疾病及訊息傳遞國際研討會暨台日細胞訊息與基因調控研討會 (Nov 10th-11th, Tainan, Taiwan).
 
Helicobacter pylori with Higher Motility Enhances Bacterial Density and Inflammatory Response in Dyspeptic Patients. (2011, Poster).
Kao CY, Sheu BS, Yang HB, Chang WL, Cheng HC, Wu JJ.
台灣微生物學會第二十屆第二次會員大會及學術研討會. Taiwan Society of Microbiology 2011 annual meeting and symposium (Dec 17th-18th, Tainan, Taiwan).
 
Gene expression and regulation of sialic acid binding adhesin (SabA) in Helicobacter pylori (2010, Oral).
Kao CY, Sheu BS, Lu CC, Wu JJ.
台灣微生物學會第二十屆第一次會員大會及學術研討會. Taiwan Society of Microbiology 2010 annual meeting and symposium (Dec 11th-12th, Taipei, Taiwan).
 
Gene expression and regulation of sialic acid binding adhesin (SabA) in Helicobacter pylori. (2006, Poster).
Kao CY, Sheu BS, Lu CC, Wu JJ.
台灣第十一屆細菌學研討會 (Aug 24th-26th, Pingtung, Taiwan).
  
Conference speaker/moderator/committee and invited talks
2019 Nov 23rd. Uncovering the secrets of bacterial pathogenesis. (Invited talk).
Taiwan Society of Microbiology 2019 annual meeting and symposium. 台灣微生物學會第二十三屆第一次會員大會及學術研討會.
National Taiwan University, Taipei, Taiwan.
 
2019 Nov 13th. Fighting antibiotic resistant bugs: exploring alternative drug targets for post-antibiotic era. (Invited talk).
En Chu Kong Hospital, New Taipei City, Taiwan.
 
2019 Nov 6th. Uncovering the secrets of bacterial pathogenesis. (Invited talk).
School of Life Sciences, National Yang-Ming University, Taipei, Taiwan.
 
2019 Sep 26th. Uncovering the secrets of bacterial pathogenesis. (Invited talk).
Department of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan.
 
2019 Aug 31st. Committee Chair - Hot topics in the 119th ASM General Meeting-細菌診斷與抗藥性新知研討會 (Co-hosted by ASM, TSM, and NYMU) National Yang-Ming University.
 
2019 Aug 31st. New pipeline drugs for post-antibiotic era. (Conference invited talk).
Hot topics in the 119th ASM General Meeting-2019細菌診斷與抗藥性新知研討會. National Yang-Ming University, Taipei, Taiwan.
 
2019 Feb 24th. Uncovering the secrets of Listeria monocytogenes pathogenesis: ‘Live' in the cytosol. (Job talk, Faculty application).
Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.
 
2019. Feb 18th. Uncovering the secrets of bacterial pathogenesis. (Invited talk).
College of medicine, National Cheng-Kung University, Tainan, Taiwan.
 
2019. Feb 13th. TrfA, a novel transcriptional regulator of fermentation, regulates cytosolic survival of 1,4-dihydroxy-2-naphthoate (DHNA) deficient Listeria monocytogenes. (Job talk, Faculty application).
Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan.
 
2019. Feb 14th. Uncovering the secrets of bacterial pathogenesis. (Job talk, Faculty application).
Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan.
 
2019 Jan 24th. TrfA, a novel transcriptional regulator of fermentation, regulates cytosolic survival of 1,4-dihydroxy-2-naphthoate (DHNA) deficient Listeria monocytogenes. (Job talk, Faculty application).
Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
 
2018 Nov 5th. A novel screen suggests that regulation of fermentation is critical for cytosolic survival and virulence of Listeria monocytogenes (Job talk, Faculty application).
Department of Microbiology and Immunology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
 
2018. Oct 31st. What makes a successful pathogen ? (Job talk, Faculty application).
Department of Life Sciences, Tunghai University, Taichung, Taiwan.
 
2018. Sep 30th. A novel screen suggests that regulation of fermentation is critical for cytosolic survival and virulence of Listeria monocytogenes. (Conference invited talk).
25th Annual Midwest Microbial Pathogenesis Conference, University of Iowa, Iowa, IA (MMPC).
 
2018 Mar 7th. Motility and metabolism, two crucial factors in bacterial pathogenesis. (Job talk, Faculty application).
Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan.
 
2018 Mar 5th. Motility and metabolism, two crucial factors in bacterial pathogenesis. (Invited talk).
Department of Biochemical Science and Technology, National Chiayi University, Chiayi 60004, Taiwan.
 
2016 May 19th. Roles of Helicobacter pylori motility in pathogenesis and its regulatory mechanism: from clinical investigation to basic research. (Job talk, Postdoctoral fellow application).
Institut Pasteur, Biology of Infection Unit, Paris, France.
 
2015 Oct 6th. Past, Present, and Future of Research in Helicobacter pylori Pathogenesis. (Job talk, Faculty application).
Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan.
 
Grants
1. 2017/10-2019/10. Postdoctoral Research Abroad Program, Ministry of Science and Technology, Republic of China, Taiwan (科技部補助赴國外從事博士後研究)
Title: Characterization of Listeria monocytogenes CFPTS gene cluster in central nervous systemic infection.
Grant number: 106-2917-I-564-070 (2,600,000 NTD)
2. 2019/10-2020/10. Ministry of Science and Technology, Republic of China, Taiwan (科技部補助學者提昇國際影響力-拋光計畫).
Title: Connect American and Taiwan societies for microbiology to promote the international visibility of microbiology research in Taiwan (連結美國與台灣微生物學會以促進台灣微生物學研究之國際能見度).
Grant number: 108-2911-I-010-508 (154,000 NTD)
3. 2020/08-2021/07. 益福生醫股份有限公司產學合作案.
Title: The effect of probiotics on anti-Helicobacter pylori activity and its mechanisms (益生菌抗幽門桿菌之功能評估及機轉探討)
Grant number: (360,000 NTD)
4. 2020/08-2021/07. 行天宮醫療志業醫療財團法人恩主公醫院醫療科技研究計畫.
Title: Molecular characterization of carbapenem-resistant Enterobacteriaceae in a regional teaching hospital in Taiwan, 2011-2019 (2011-2019年台灣區域教學醫院抗碳青黴烯腸桿菌分子特性分析)
Grant number: (350,000 NTD)
5. 2020/08-2023/07. Ministry of Science and Technology, Republic of China, Taiwan (科技部專題研究計畫-新進人員研究計畫).
Title: Characterization of the role(s) of PASTA kinase-mediated signaling pathways in resistance of Staphylococcus aureus to β-lactam antibiotics (探討PASTA激酶訊息路徑於金黃色葡萄球菌對β-內醯胺類抗生素抗藥性之角色)
Grant number: 109-2320-B-010-036-MY3 (4,500,000 NTD)
 
Editorial Board Member

  • Trends in Clinical Microbiology (2018 ~)
  • Peer Nest (2019 ~)
 
Peer Reviewer for Academic Journals
  • Acta Biomaterialia (SCI, Impact factor: 7.242, 2018 ~)
  • BBA Gene Regulatory Mechanisms (SCI, Impact factor: 3.510, 2018 ~)
  • Trends in Clinical Microbiology (2018 ~)
  • Microbial Pathogenesis (SCI, Impact factor: 2.914, 2019 ~)
  • Heliyon (2019 ~)
  • Practical Laboratory Medicine (2019 ~)
  • Frontiers in Cellular and Infection Microbiology (SCI, Impact factor: 4.123, 2020 ~)
  • Infectious Disorders-Drug Targets (2020 ~)

 
Professional Service

  • 2019-2021. American Society for Microbiology (ASM) Young Ambassador to Taiwan. 2019美國微生物學會駐台灣青年大使.
  • 2019-2022 Deputy Secretary: Taiwan Society of Microbiology, 台灣微生物學會第23屆副秘書長

 
Honors and Awards

  • 2020. Outstanding alumni, Department of Biochemical Science and Technology, National Chia-Yi University. 嘉義大學生化科技學系108年度傑出系友.
  • 2019. ASM Young Ambassador/Travel Award.119 美國微生物學會年會 American Society for Microbiology 2019 119th General Meeting, SF, USA.
  • 2019-2021. American Society for Microbiology (ASM) Young Ambassador to Taiwan. 2019美國微生物學會駐台灣青年大使.
  • 2018. MMPC Fellowship/Travel Award. 25th Annual Midwest Microbial Pathogenesis Conference (MMPC), University of Iowa, Iowa, IA.
  • 2017. 科技部補助國內專家學者出席國際學術會議. MOST Travel Grant Award (The 27th European Congress of Clinical Microbiology and Infectious Diseases, ECCMID). Ministry of Science and Technology, Taiwan.
  • 2016. Taiwan Society of Microbiology. 2nd prize for oral presentation at the 2016 annual meeting and symposium. (Basic microbiology research).
  • 台灣微生物學會第二十二屆第一次會員大會及學術研討會口頭論文基礎微生物學組第二名.
  • Helicobacter pylori J99 jhp0106 Gene, Under the Control of CsrA/RpoN Regulatory System, Modulates Flagella Formation and Motility.
  • Kao CY, Chen JW, Wang S, Sheu BS, Wu JJ.
  • 2016. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2016 annual meeting and symposium. (Clinical microbiology research).
  • 台灣微生物學會第二十二屆第一次會員大會及學術研討會口頭論文臨床微生物學組第一名.
  • Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015. Kao CY, Wu HM, Lin WH, Tseng CC, Yan JJ, Wans MC, Teng CH, Wu JJ.
  • 2015. 科技部補助國內專家學者出席國際學術會議. MOST Travel Grant Award (American Society for Microbiology 2015 115th General Meeting). Ministry of Science and Technology, Taiwan.
  • 2014. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2014 annual meeting and symposium. (Basic microbiology research).
  • 台灣微生物學會第二十一屆第二次年會口頭論文基礎微生物學組第一名.
  • Roles of Helicobacter pylori motility in pathogenesis and its regulatory mechanism: From clinical investigation to basic research.
  • Kao CY, Sheu BS, Wu JJ.
  • 2013. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2013 annual meeting and symposium. (Clinical microbiology research).
  • 台灣微生物學會第二十一屆第一次年會口頭論文臨床微生物學組第一名.
  • Heteroresistance of Helicobacter pylori within the same patient prior to antibiotic treatment.
  • Kao CY, Lee AY, Huang AH, Song PY, Yang YJ, Sheu SM, Chang WL, Sheu BS, Wu JJ.
  •  2013. 科技部補助國內研究生出席國際學術會議. MOST Travel Grant Award (American Society for Microbiology 2013 113th General Meeting). Ministry of Science and Technology, Taiwan.
  •  2012. Taiwan Society of Microbiology. 1st prize for best oral presentation at the 2012 annual meeting and symposium. (Basic microbiology research).
  • 台灣微生物學會第二十屆第三次年會口頭論文基礎微生物學組第一名.
  • CsrA regulates H. pylori motility and adhesion ability through controlling alternative sigma factor rpoN expression and flagella formation.
  • Kao CY, Sheu BS, Wu JJ.