Faculty

Current Position

2021 – present: Associate Professor, Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan

2013 – 2021: Assistant Professor, Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan

Office

Room 406, Biomedical Building

Academic Degrees

M.D., Trakia University, Stara Zagora, Bulgaria

Ph.D., Duke University, Durham, NC, USA

 

Experience

1. 2007-2012: 

Postdoctroral fellow, Molecular and Cell Biology Department, University of California, Berkeley, USA

Mentor: Ellen A Robey, PhD

Project: Visualizing the negative selection in the thymus

2. 2001-2007: PhD in Immunology, Duke University, Durham, NC

Advisor: You-Wen He, M.D., Ph.D. 

Dissertation: The role of the anti-apoptotic molecules Bcl-2 and Mcl-1 in the development and function of the immune 

system3. 1994-2000: Doctor of Medicine, Trakia University Medical School, Stara Zagora, Bulgari

 

Honors and Awards

2016 – Outstanding poster award at the Frontiers in Glycoscience: Hostpathogen interactions, Academia Sinica, Taipei, Taiwan
2015 – Outstanding poster award at the Glycoscience Symposium, 
Academia Sinica, Taipei, Taiwan
2010 – 2012: Irvington Institute postdoctoral fellowship of the Cancer 
Research Institute

Editor for 

Frontiers in Cell and Developmental Biology

Ad hoc reviewer for

Scientific Reports, Autophagy, Frontiers in Cell and Developmental Biology

Specialty

Thymus. T cell development, macrophages, phagocytosis, efferocytosis, fibroblasts, Heparan sulfate, heparin, mast cells

Invited speaker

2021 – Speaker at 10x Genomics monthly event
2019 – 25th International Symposium on Glycoconjugates (Glyco25), Milan, Italy
2019 – Taiwan GlycoForum Retreat, Pacific Hot Spring Hotel Green Bay, New Taipei city, Taiwan
2016 - Frontiers in Glycoscience: Host-pathogen interactions, Academia Sinica, Taipei, Taiwan
2015 – Glycoscience Symposium, Academia Sinica, Taipei, Taiwan
2013 – Chang Gung University, Taoyuan, Taiwan
2012 – Academia Sinica, Taipei, Taiwan
2012 – National Yang-Ming University, Taipei, Taiwan
2011 – EUThyme Rolduc meeting, Noordwijkerhout, Netherlands
2011 – American Association of Immunologists meeting, San Francisco, CA
2010 – 14th International Congress of Immunology, Kobe, Japan
2010 – National Yang-Ming University, Taipei, Taiwan
2010 – National Taiwan University, Taipei, Taiwan

Publications

1. Tsai TL, Zhou TA, Hsieh YT, Wang JC, Cheng HK, Huang CH, Tsai PY, Fan HH, Feng HK, Huang YC, Lin CC, Lin CH, Lin CY, Dzhagalov IL, Hsu CL; Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to 

cope with efferocytosis-associated stress. Cell Rep. 2022; Jul 12;40(2):111065. doi: 10.1016/j.celrep.2022.111065.

2. Fan HH, Tsai TL, Dzhagalov IL, Hsu CL; Evaluation of Mitochondria Content and Function in Live Cells by Multicolor Flow Cytometric Analysis. Methods Mol Biol. 2021;2276:203-213. doi: 10.1007/978-1-0716-1266-8_15

3. Hsu HP, Chen YT, Chen YY, Lin CY, Chen PY, Liao SY, Lim CCY, Yamaguchi Y, Hsu CL, Dzhagalov IL; Heparan sulfate is essential 

for thymus growth. J Biol Chem. 2021 Feb 15:100419. doi: 10.1016/j.jbc.2021.100419. 

4. Chu CF, Feng HK, Sun KH, Hsu CL, Dzhagalov IL; Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue 

Slices Reveals That Fas Is Dispensable for Negative Selection. Front. Cell Dev. Biol. 8:586807. doi: 10.3389/fcell.2020.586807

5. Maslova A, Ramirez RN, Ma K, Schmutz H, Wang C, Fox C, Ng B, Benoist C, Mostafavi S; Immunological Genome Project. Deep 

3 learning of immune cell differentiation. Proc Natl Acad Sci U S A. 2020 Sep 25:202011795. doi: 10.1073/pnas.2011795117.

6. Immunological Genome Project. ImmGen at 15. Nat Immunol. 2020 Jul;21(7):700-703. doi: 10.1038/s41590-020-0687-4.

7. Chou YJ, Lin CC, Dzhagalov IL, Chen NC, Lin CH, Lin CC, Chen ST, Chen KH, Fu SL. Vaccine adjuvant activity of a TLR4-

activating synthetic glycolipid by promoting autophagy. Sci Rep.2020 May 21;10(1):8422. Doi: 10.1038/s41598-020-65422-1 

8. Zhou TA, Hsu CL, Dzhagalov IL. Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Methods Mol 

Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17.

9. Kurd NS, Lutes LK, Yoon J, Chan SW, Dzhagalov IL, Hoover AR, Robey EA. A role for phagocytosis in inducing cell death during 

thymocyte negative selection. Elife. 2019 Dec 23;8. pii: e48097

10.Fontaine MAC, Westra MM, Bot I, Jin H, Franssen AJPM, Bot M, de Jager SCA, Dzhagalov I, He YW, van Vlijmen BJM, Gijbels MJJ, Reutelingsperger CP, van Berkel TJC, Sluimer JC, Temmerman L, Biessen EAL. Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Sci Rep.2019 Oct 10;9(1):14547. doi: 10.1038/s41598-019-51020-3.

11.Hsu C-L, Dzhagalov IL. Metabolite Transporters—The Gatekeepers for T Cell Metabolism. Immunometabolism. 2019;1:e190012. https://doi.org/10.20900/immunometab20190012

12.Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang 

HR, Jung JU, Ting JP. NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019 

Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. Epub 2019 Mar 19.

13.Wei CW, Zhou TA, Dzhagalov IL, Hsu CL. Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes 

in T Cells. J. Vis. Exp. 2019 Jan 8;(143), e58844, doi:10.3791/58844