Faculty

Current Position

Professor, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University

Professor, Institute of Food Safety & Health Risk Assessment, National Yang Ming Chiao Tung University

Office

Room 312, Biomedical Building

 

Academic Degrees

Ph.D. Department of Microbiology, The University of Iowa, USA
M.S. Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan
B.S. Department of Agricultural Chemistry, National Taiwan University, Taiwan

 

Experience

Vice president, Office of International Affairs, NYCU
Director, Institute of Microbiology and Immunology, National Yang-Ming University
Ambassador to Taiwan, American Society for Microbiology
Chair, Department of Life Sciences, National Central University, Taiwan
Director, Center for Biotechnology & Biomedical Engineering, NCU
Director, Division of Planning, Office of R&D, NCU, Taiwan
Professor, Department of Biomedical Science and Engineering, NCU
Professor, Institute of Systems Biology and Bioinformatics, NCU
Professor, Graduate Institute of Environmental Engineering, NCU
Research Fellow, Development Center for Biotechnology, Taiwan 
Postdoctoral Fellow, Eli Lilly & Co., Indianapolis, US

Specialty

Bacterial biochemistry/physiology, Microbiota, Proteomics

Research Interests

1. Microbial biochemistry, physiology and proteomics
- Bacterial isolation, identification and characterization
- Purification, characterization and applications of microbial enzymes
2. Microbiota and health/diseases
3. Microbial catabolism of toxic compounds (endocrine disrupting chemicals, surfactants, food additives)

 

Selected Publications

1. guyen, Ngoc Tuan, Wei-Hsin Sun, Tzu Hsuan Chen, Po-Chun Tsai, Chih-Chen Chen, ShirLy Huang*. 2022. Gut mucosal microbiome is perturbed in rheumatoid arthritis mice and partly restored after TDAG8 deficiency or suppression by salicylanilide derivative. International Journal of Molecular Sciences 23(7): 3527.
2. Weng, Chen-Tsung, Shir-Ly Huang, Hui-Wen Yang, Chih-Chin Kao, Cheng-Chung Wei, Yu-Feng Huang. 2022. Oral microbiota in xerostomia patients – a preliminary study. Journal of Dental Sciences 17(1): 324-330. (Epub August 28, 2021)
3. Phan, Ha My Ti, Marina L. Sidorenko, Po-Chun Tsai, Shir-Ly Huang*. 2021. Wholegenome shotgun sequence of Bacillus mycoides strain U53, a psychrotolerant bacterium Isolated from Sakhalin Region, Russia. Microbiology Resource Announcements 10(1): e01257-20.
4. Dai, Shih-Ping, Wei-Shan Hsieh, Chien-Hua Chen, Yueh-Hao Lu, Hsu-Shan Huang, DerMing Chang, Shir-Ly Huang, Wei-Hsin Sun*. 2020. TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain. Journal of Neuroinflammation 17(1): 170
5. Rajendran, Ranjith Kumar, Yi-Wen Lee, Pei-Hsin Chou, Shir-Ly Huang, Roland Kirschner*, Chu-Ching Lin*. 2020. Biodegradation of the endocrine disrupter 4-t-octylphenol by the nonligninolytic fungus Fusarium falciforme RRK20: Process optimization, estrogenicity assessment, metabolite identification and proposed pathways. Chemosphere 240, 124876.
6. Madda, Rashmi, Shih-Chang Lin, Wei- Hsin Sun*, Shir-Ly Huang*. 2019. Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis. Journal of Microbiology, Immunology and Infection 52(5), 816-826.
7. Hung, Kuo-Chan, Ngoc Tuan Nguyen, Yu-Ling Sun and Shir-Ly Huang*. 2019. Bio-Fenton reaction involved in the cleavage of the ethoxylate chain of nonionic surfactants by dihydrolipoamide dehydrogenase from Pseudomonas nitroreducens TX1. Scientific Reports 9(1), 6827.
8. Lim, Jae Yun, Munkhtsatsral Ganzorig, Shir-Ly Huang and Kyoung Lee. 2019. First Complete Genome Sequence of Haematobacter massiliensis OT1 (Chromosome and Multiple Plasmids), Isolated from Human Skin. Microbiology Resource Announcements 8(18), e00292-19.
9. Madda, Rashmi, Shih-Chang Lin, Wei-Hsin Sun* and Shir-Ly Huang*. 2018. Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification. PeerJ (6), e4730.
10. Lim, Jae Yun, Ingyu Hwang, Munkhtsatsral Ganzorig, Shir-Ly Huang, Gyu-Sung Cho, Charles M. A. P. Franz, Kyoung Lee. 2018. Complete genome sequences of three Moraxella osloensis strains isolated from human skin. Genome Announc 6(3), e01509-17.
11. Hsieh, Wei-Shan, Chia-Chi Kung, Shir-Ly Huang, Shih-Chang Lin and Wei-Hsin Sun. 2017.  TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis. Scientific Reports 7, 8870.
12. Rajendran, Ranjith Kumar, Chu-Ching Lin, Shir-Ly Huang, Roland Kirschner. 2017. Enrichment, isolation, and biodegradation potential of long-branched chain alkylphenol degrading non-ligninolytic fungi from wastewater. Marine Pollution Bulletin 125(1-2), 416-425.
13. Kirschner, Roland, Pei-Lun Sun, Shir-Ly Huang, Chien-Lung Chen, Chih-Ping Yang. 2017. A case of bilateral otomycosis associated with Aspergillus flavus and A. terreus in Taiwan. Journal de Mycologie Médicale 27(3), 412-416.
14. Rajendran, Ranjith kumar, Shir-Ly Huang, Chu-Ching Lin, Roland Kirschner. 2017. Biodegradation of the endocrine disrupter 4-tert-octylphenol by the yeast strain Candida rugopelliculosa RRKY5 via phenolic ring hydroxylation and alkyl chain oxidation pathways. Bioresource Technology 226, 55-64.
15. Tuan, Ngoc Nguyen, Chen-Wei Yeh, Po-Chun Tsai, Kyoung Lee, Shir-Ly Huang *. 2016. Transposon mutagenesis identifies genes critical for growth of Pseudomonas nitroreducens TX1 on octylphenol polyethoxylates. Applied and Environmental Microbiology 82(22), 6584-6592.
16. Rajendran, Ranjith Kumar, Shir-Ly Huang, Chu-Ching Lin, Roland Kirschner. 2016. Aerobic degradation of estrogenic alkylphenols by yeasts isolated from a sewage treatment plant. RCS Advances 6, 82862–82871.
17. Lin, Yi-Wen, Chia-Chin Yang, Nguyen Ngoc Tuan, Shir-Ly Huang*. 2016. Diversity of octylphenol polyethoxylate-degrading bacteria: with a special reference to Brevibacterium sp. TX4. International Biodeterioration & Biodegradation 115, 55-63.
18. Lin, Yi-Wen, Nguyen Ngoc Tuan, Shir-Ly Huang*. 2016. Metaproteomic analysis of the microbial community present in a thermophilic swine manure digester to allow functional characterization: A case study. International Biodeterioration & Biodegradation 115, 64-73.
19. Lin, Ting-Hsiang, Gia-Luen Guo, Wen-Song Hwang, Shir-Ly Huang*. 2016. The addition of hydrolyzed rice straw in xylose fermentation by Pichia stipitis to increase bioethanol production at the pilot-scale. Biomass and Bioenergy 91, 204-209.
20. Huang, Shir-Ly*, Nguyen Ngoc Tuan, and Kyoung Lee. 2016. Occurrence, human intake and biodegradation of estrogen-like nonylphenols and octylphenols. Current Drug Metabolism 17(3), 293-302.
21. Mulla, Sikandar I., Anyi Hu, Yuwen Wang, Qian Sun, Shir-Ly Huang*, Han Wang and Chang-Ping Yu*. 2016. Degradation of triclocarban by a triclosan-degrading Sphingomonas strain YL-JM2C. Chemosphere 144, 292-296.

Patent

1. R.O.C -  593173, I 240001, I258505,I 265173, I 368736, I502199, I 533871, I 533869

2. US - US 8,603,785 B2, US7,527,964, US7,405,067B2, US7,332,325B2,US7,115,411B2, US9,192,602, US9,284,281

3. Japan - 特許第 4601394 號, 特許第 4522798 號, 特許第 4454471 號, 特許第 3967741