National Yang Ming Chiao Tung University

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Faculty

Tsai, Ming-Han / 蔡明翰

Institute of Microbiology & Immunology

 02-2826-7000 # 67109；65242
 
 m.tsai@nycu.edu.tw

Lab Website

https://wisewind1005.wixsite.com/tsaimh-ebv 


Current Position

Assistant Professor, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan


Education

1. University of Heidelberg, Heidelberg, Germany

    Graduate research with Prof. Dr. Henri-Jacques Delecluse (Oct. 2010 – Jan. 2015)

     Ph.D., Medical faculty (Honor: Summa Cum Laude 2015, Heidelberg, Germany)

     Ph.D. program, Helmholtz International Graduate School for Cancer Research, DKFZ

     Thesis: Identification and phenotypic characterization of a highly pathogenic Epstein-Barr virus strain


2. National Tsing-Hua University, Taiwan

    M.Sc. in Biotechnology with Dr. Tse-Wen Chang and Dr. Nan-Shih Liao (Sep. 2004- Jun.2006)

    (Honor: Honorary member, The Phi Tau Phi Scholastic Honor Society, Taiwan)

    Thesis: Study of Central and Peripheral Tolerance in the Autoimmune Prone IL-15 Receptor alpha Chain Gene Knockout mice 

    B.Sc. in Life Science (Sep. 2000 – Jun. 2004)


Current Research Interests

We are interested in Epstein-Barr virus (EBV), a human tumor virus that causes human cancers, including nasopharyngeal carcinoma, gastric cancer, breast cancer, B- and T-cell lymphomas, and various types of human autoimmune diseases, such as multiple sclerosis. We are investigating:

1. Molecular and Cellular virology of tumor viruses

2. The pathogenic roles of Epstein-Barr virus in human carcinomas and lymphomas

3.Apply virology

4. The development of vaccines and anti-viral drugs against Epstein-Barr virus and other viruses

5. Immunotherapy by using viruses

6. Virology and drug screening of SARS-CoV-2 for solving COVID-19 pandemic


RESEARCH EXPERIENCE

Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei city, Taiwan

Assistant Professor (Feb. 2018 – Present)

German Cancer Research Center, Heidelberg, Germany

Full time postdoctoral Scientist (Jan. 2015 – Dec. 2017) with Prof. Dr. Henri-Jacques Delecluse

National Health Research Institute, Taiwan

Project research assistant with Dr. Andrew Yueh Yueh (Jan. 2008 – May. 2010)


Honors

Awards

Ta-You Wu Memorial Award (國科會吳大猷先生紀念獎), 2023

MOST Young Scholar Fellowship, Taiwan (科技部年輕學者養成計畫，哥倫布計畫), May.2018-April.2023.

Excellent mentor,  National Yang Ming Chiao Tung University, Taipei, Taiwan, Sep. 2021

Best poster presentation in Nasopharyngeal Carcinoma conference, Gordon Research Conference in Hong Kong, July 2016

Best Ph.D. grade (Summa Cum Laude) in Medical faculty at University of Heidelberg, May 2015 in graduation ceremony.

Reader Favorite Award, “Dance Your PhD 2013”, Understanding the role of MYCN in Neuroblastoma using a systems Biology Approach, Science magazine/AAAS, Nov. 2013 http://www.sciencemag.org/news/2013/11/dance-your-phd-finalists-announced

Best M.Sc. grade (Honorary member, The Phi Tau Phi Scholastic Honor Society) in Biotechnology at National Tsing-Hua University, June 2006 in graduation ceremony.


Funding

MOST Young Scholar Fellowship, Taiwan (May. 2018- April. 2023)

José Carreras Leukemia Foundation (Postdoctoral research, DKFZ, Germany)

Helmholtz International Graduate School for Cancer Research, DKFZ, scholarship (Nov. 2010 – Oct. 2013)

PUBLICATIONS (Within Five years)

  • Jo-Ning Hung, Di Ngoc Kha Vo, Ha Phan Thanh Ho, Ming-Han Tsai* (2022, Aug). PEDOT:PSS in solution form exhibits a strong potential in inhibiting SARS-CoV-2 infection of the host cells by targeting viruses and also the host cells. Biomacromolecules-ACS publications, https://doi.org/10.1021/acs.biomac.2c00271.
  • Hsin Yeh, Di Ngoc Kha Vo, Zhi-Hu Lin, Ha Phan Thanh Ho, Wei-Jyun Hua, Wei-Lun Qiu, Ming-Han Tsai*, Tung-Yi Lin* (2022, May). GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus. PHYTOMEDICINE, 103:154215. doi: 10.1016/j.phymed.2022.154215. 
  • Jen-Mei Chou, Jo-Ling Tsai, Jo-Ning Hung, I-Hua Chen, Szu-Ting Chen, Ming-Han Tsai* (2022, May). The ORF8 Protein of SARS-CoV-2 Modulates the Spike Protein and Its Implications in Viral Transmission. Frontiers in Microbiology, 19;13:883597.
  • Han-Yun Hsieh, Ray Chang, Yung-Yu Huang, Po-Han Juan, Hidetoshi Tahara, Kuan-Yi Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan (2022, Jan). Continuous polymerase chain reaction microfluidics integrated with a gold-capped nanoslit sensing chip for Epstein-Barr virus detection. Biosensors and Bioelectronics, 10.1016/j.bios.2021.113672. MOST 110-2636-B-A49-002. 
  • Zhe Li, Francesco Baccianti, Susanne Delecluse, Ming-Han Tsai, Anatoliy Shumilov, Xianliang Cheng, Sicong Ma, Ingrid Hoffmann, Remy Poirey, Henri-Jacques Delecluse (2021, Oct). The Epstein-Barr virus non-coding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth. PNAS, 118 (43) e2115508118. MOST 109-2636-B-010-007. 
  • Susanne Delecluse, Remy Poirey, Martin Zeier, Paul Schnitzler, Uta Behrends, Ming-Han Tsai*, Henri-Jacques Delecluse* (2020, Feb). Identification and cloning of a new western Epstein-Barr virus strain that replicates efficiently in primary B cells. JOURNAL OF VIROLOGY, pii: JVI.01918-19. doi: 10.1128/JVI.01918-19.
  • Susanne Delecluse, Jiyang Yu, Katharina Bernhardt, Janina Haar, Remy Poirey, Ming-Han Tsai, Rama Kiblawi, Annette Kopp-Schneider, Paul Schnitzler, Martin Zeier, Peter Dreger, Patrick Wuchter, Olcay Cem Bulut, Uta Behrends, Henri-Jacques Delecluse (2019, Sep). Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs. PLoS One, 30;14(9):e0222847. 
  • Zhe Li*, Ming-Han Tsai*, Anatoliy Shumilov, Francesco Baccianti, Sai Wah Tsao, Remy Poirey & Henri-Jacques Delecluse (2019, Sep). Epstein-Barr virus ncRNA from a nasopharyngeal carcinoma induces an inflammatory response that promotes virus production. Nature Microbiology, 4(12):2475-2486. 
  • Jia-Ni Tian, Chi-Chen Yang, Chiu-Kai Chuang, Ming-Han Tsai, Ren-Huang Wu, Chiung-Tong Chen, Andrew Yueh (2019, Aug). A Dengue Virus Type 2 (DENV-2) NS4B-Interacting Host Factor, SERP1, Reduces DENV-2 Production by Suppressing Viral RNA Replication. Viruses-Basel, 27;11(9). pii: E787. 
  • Susanne Delecluse, Ming-Han Tsai, Anatoliy Shumilov, Maja Bencun, Sebastian Arrow, Aisha Beshirova, Andréa Cottignies-Calamarte, Felix Lasitschka, Olcay Cem Bulut, Christian Münz, Martin Zeier, Uta Behrends, Henri-Jacques Delecluse (2019, Feb). Epstein-Barr Virus Induces Expression of the LPAM-1 Integrin in B Cells In Vitro and In Vivo. JOURNAL OF VIROLOGY, doi: 10.1128/JVI.01618-18.
  • Dwain G. van Zyl, Ming-Han Tsai, Anatoliy Shumilov, Viktor Schneidt, Rémy Poirey, Bettina Schlehe, Herbert Fluhr, Josef Mautner, Henri-Jacques Delecluse (2018, Dec). Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice. PLoS Pathogens, 14(12):e1007464. 
  • Maja Bencun, Olaf Klinke, Agnes Hotz-Wagenblatt, Severina Klaus, Ming-Han Tsai, Remy Poirey, Henri-Jacques Delecluse (2018, Feb). Translational profiling of B cells infected with the Epstein-Barr virus reveals 5′ leader ribosome recruitment through upstream open reading frames. NUCLEIC ACIDS RESEARCH, 46(6), 2802-2819. 
  • Soham Gupta, Päivi Ylä-Anttila, Simone Callegari, Ming-Han Tsai, Henri-Jacques Delecluse, Maria G. Masucci (2018, Jan). Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome. PLoS Pathogens, 22;14(1):e1006852. 
  • Henri-Jacques Delecluse, Susanne Fink, Ming-Han Tsai, Anatoliy Shumilov (2017, Jul). The Epstein-Barr virus and the centriole: new tricks from an old dog. Médecine sciences : M/S., 33(6-7), 567-569. 
  • Ren-Huang Wu, Ming-Han Tsai, Kuen-Nan Tsai, Jia Ni Tian, Jian-Sung Wu, Su-Ying Wu, Jyh-Haur Chern, Chun-Hong Chen, Andrew Yueh (2017, Jun). Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments. JOURNAL OF VIROLOGY, 91(12), e01836-16. 
  • Andrea Bilger, Julie Plowshay, Shidong Ma, Dhananjay Nawandar, Elizabeth A. Barlow, James C. Romero-Masters, Jillian A. Bristol, Zhe Li, Ming-Han Tsai, Henri-Jacques Delecluse, Shannon C. Kenney (2017, May). Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication. Oncotarget, 8(27), 44266-44280. 
  • Shi-Dong Ma*, Ming-Han Tsai*, James C. Romero-Masters, Erik A. Ranheim, Shane M. Huebner, Jillian A. Bristol, Henri-Jacques Delecluse, Shannon C. Kenney (*co-first author, listed by last name alphabetically) (2017, Apr). Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential. JOURNAL OF VIROLOGY, 91(7), e01928-16. 
  • Anatoliy Shumilov*, Ming-Han Tsai*, Yvonne T. Schlosser, Anne-Sophie Kratz, Katharina Bernhardt, Susanne Fink, Tuba Mizani, Xiaochen Lin, Anna Jauch, Josef Mautner, Annette Kopp-Schneider, Regina Feederle, Ingrid Hoffmann & Henri-Jacques Delecluse (*co-first author, listed by last name alphabetically) (2017, Feb). Epstein-Barr virus particles induce centrosome amplification and chromosomal instability. Nature Communications, 10;8, 14257. 
  • Ming-Han Tsai, Xiaochen Lin, Anatoliy Shumilov, Katharina Bernhardt, Regina Feederle, Remy Poirey, Annette Kopp-Schneider, Bruno Pereira, Raquel Almeida, Henri-Jacques Delecluse (2017, Feb). The biological properties of different Epstein-Barr virus strains explain their association with various types of cancers. Oncotarget, 8(6), 10238-10254.


Presentation

  1. SARS-CoV-2 research: The impact of viral accessory protein on viral transmission or evolution and the strategy for developing the anti-viral drugs against viral infection. (Invited speaker), Department of Life Science, National Dong Hwa University, May 29, 2022
  2. 新冠病毒研究: 病毒輔助蛋白對病毒傳播及演化可能造成之影響及針對病毒感染宿主之機制進行藥物開發.(Invited speaker)台灣微生物生態學學會年會, May 28, 2022
  3. Impacts of strain variation on EBV virology. (Invited speaker) 9th Nasopharyngeal carcinoma NPC research Day and 11th NPCSM AGS, Mar 2021 
  4. The Pathogenic Roles of Epstein-Barr virus in Human Cancers. (Invited speaker)台灣兒童感染症醫學會及病毒學學會聯合學術研討會Oct 28, 2018. 
  5. The Epstein-Barr virus induces the expression of LPAM-1 in B-cells to access the gastrointestinal mucosa-associated lymphoid tissues. 18th International Symposium on EBV and associated diseases, Madison, Wisconsin, July 28-Aug 1, 2018. 
  6. The M81 Epstein-Barr Virus associated RNA 2 Enhances CXCL8 production and Spontaneous vius lytic replication in primary B lymphocytes. (Oral Presentation) Nasopharyngeal Carcinoma, Gordon Research Conference, Hong Kong, June 24-29, 2018. 
  7. The Epstein-Barr virus BART miRNA cluster of the nasopharyngeal carcinoma-associated M81 strain modulates lytic replication and cell growth in primary B cells. (Oral Presentation) 17th International Symposium on EBV and associated diseases, Zürich, Switzerland, Aug 8-12, 2016. 
  8. The Epstein-Barr virus BART miRNA cluster of the nasopharyngeal carcinoma-associated M81 strain modulates lytic replication and cell growth in primary B cells. Nasopharyngeal Carcinoma, Gordon Research Conference, Hong Kong, June 26-July 1, 2016. 
  9. Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas. EMBO meeting, Amsterdam, Sep 21-24 , 2013.