Faculty

Current Position

2020-   Chairman in Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University
2019-   Distinguished Professor in Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University
2016-   Joint appointments: Department of Biochemistry, Kaohsiung Medical University
2007-   Joint appointments: Institute of Clinical Medicine, Institute of Biomedical Informatics and Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University

Office

·     Rm 623, Library, Information and Research Building

Academic Degrees

1994-1998  Postdoc in Molecular Pharmacology (Laboratory of James E. Ferrell, Jr., Stanford University) 
1988-1994  Ph.D. in Biochemistry and Biophysics (Laboratory of Donald J. Graves, Iowa State University)

Experience

2019-2022 Board of Director at PharmaEngine Inc. (Legal Representative of The National Development Fund, Executive Yuan)
2018-2020 Deputy Director in Biomedical Engineering Research and Development Center, National Yang Ming Chiao Tung University
2018-2020 Coach of SPARK program at National Yang Ming Chiao Tung University
2011-2019 Professor in Institute of Biopharmaceutical Sciences, National Yang-Ming University
2011-2017  Chairman in Institute of Biopharmaceutical Sciences, National Yang-Ming University
2007-2011 Professor in Institute of Clinical Medicine,National Yang-Ming University
2005-2007 Associate Investigator in Institute of Cancer Research, National Health Research Institutes
2003-2005 Associate Investigator in Division of Molecular and Genomic Medicine, NHRI
1998-2003 Assistant Investigator in Division of Molecular and Genomic Medicine, NHRI

Specialty

drug development, bioinformatics, systems biology

Research Interests

Drug repurposing for the treatment of cancer and Alzheimer’s disease, development of drug-biomarker pairs for precision medicine

Drug development

CY001: Development of cancer stem cell chemical inhibitor for lung adenocarcinoma. Currently, CY001 has complete the phase 1b clinical trial. 
YQ1: Development of cancer stem cell inhibitor (herbal medicine YQ1) for lung adenocarcinoma. Currently, YQ1 has complete the phase 2 clinical trial. 

Major awards and honors

Leukemia Society of America Career Development Award (1998-1999)
Leukemia Society of America Fellowship (1996-1998)
Keystone Symposium Travel Award (1997)
Stanford Dean’s Postdoctoral Fellowship (1994-1995)
Graduate Research Excellence Award (Iowa State University) (1994)
The Honor Society of Agriculture (Gamma Sigma Delta) (1989)
The 14th National Innovation Award (2017)
The 18th National Innovation Award (2021)

Patents-24 patents

Selected Publications from 190 international papers

1. Chi-Tai Yeh, Alexander TH Wu, Peter M-H Chang, Kuan-Yu Chen, Chia-Ning Yang, Shuenn-Chen Yang, Chao-Chi Ho, Chun-Chi Chen, Yu-Lun Kuo, Pei-Ying Lee, Yu-Wen Liu, Chueh-Chuan Yen, Michael Hsiao, Pei-Jung Lu, Jin-Mei Lai, Liang-Shun Wang, Chih-Hsiung Wu, Jeng-Fong Chiou, Pan-Chyr Yang*, and Chi-Ying F. Huang*. Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. American Journal of Respiratory and Critical Care Medicine 186(11):1180-8 (2012) (*corresponding author)
2. Hui-Wen Cheng, Yu-Hsin Liang, Yu-Lun Kuo, Chih-Pin Chuu, Ching-Yu Lin, Meng-Hua Lee, Alexander T. H. Wu, Chi-Tai Yeh, Edmund I-Tsuen Chen, Jacqueline Whang-Peng, Chun-Li Su*, Chi-Ying F. Huang*. Identification of Thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death and Disease 6:e1753 (2015). (*corresponding author)
3. Chun-Li Su, Chia-Ling Tseng, Chintakunta Ramesh, Hsiao-Sheng Liu, Chi-Ying F. Huang*, Ching-Fa Yao*. Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction. European Journal of Medicinal Chemistry 132:90-107 (2017) (*corresponding author)
4. Shu-Fang Lin, Jia-Ying Chien, Chi-Ying F. Huang*, Shun-Ping Huang*. Oroxylin A Promotes Retinal Ganglion Cell Survival in a rat optic nerve crush model.  PLOS ONE 12(6):e0178584 (2017). (*corresponding author)
5. Shen-Jeu Won, Cheng-Hsin Yen, Hao-Wen Hsieh, Shao-Wei Chang, Chun-Nan Lin, Chi-Ying F. Huang*, Chun-Li Su*. Using connectivity map to identify natural lignan justicidin A as a NF-kB suppressor. Journal of Functional Foods 34: 68–76 (2017). (*corresponding author)
6. Yu-Feng Hu*, Yao-Ting Chang, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yen-Hua Huang, Tze-Tze Liu, Che-Hong Chen, Ta-Chuan Tuan, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Abigail Louise D. Te, Chi-Ying F. Huang*, Shih-Ann Chen. The roles of alcohol dehydrogenase in patients with atrial fibrillation. Pacing and Clinical Electrophysiology 40(12):1446-1453 (2017) (*corresponding author)
7. Pi-Lin Sung, Kuo-Chang Wen, Yi-Jen Chen, Ta-Chung Chao, Yi-Fang Tsai, Ling-Ming Tseng, Jian-Tai Timothy Qiu, Kuan-Chong Chao, Hua-Hsi Wu, Chi-Mu Chuang, Peng-Hui Wang*, Chi-Ying F. Huang*. The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels. PLOS ONE 12(9):e0185615 (2017) (*corresponding author)
8. Peter Mu-Hsin Chang, Che-Hong Chen, Chi-Chun Yeh, Hsueh-Ju Lu, Tze-Tze Liu, Ming-Huang Chen, Chun-Yu Liu, Alexander T. H. Wu, Muh-Hwa Yang, Shyh-Kuan Tai, Daria Mochly-Rosen, Chi-Ying F. Huang*. Transcriptome analysis and prognosis of ALDH isoforms in human cancer. Scientific Reports 8(1):2713 (2018)
9. Cheng-Wei Chu, Huey-Jiun Ko, Chia-Hua Chou, Tai-Shan Cheng, Hui-Wen Cheng, Yu-Hsin Liang, Yun-Ling Lai, Chen-Yen Lin, Chihuei Wang, Joon-Khim Loh, Jiin-Tsuey Cheng, Shean-Jaw Chiou, Chun-Li Su, Chi-Ying F. Huang*, and Yi-Ren Hong*. Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells. International Journal of Molecular Sciences 20(3):473 (2019) (*corresponding author)
10. Jing-Ming Chen, Ting-Ting Yang, Tai-Shan Cheng, Ting-Fen Hsiao, Peter Mu-Hsin Chang, Jyh-Yih Leu, Feng-Sheng Wang, Shih-Lan Hsu, Chi-Ying F. Huang, Jin-Mei Lai. Modified Sijunzi decoction can alleviate cisplatin-induced toxicity and prolong the survival time of cachectic mice by recovering muscle atrophy. Journal of Ethnopharmacology 233:47-55 (2019)
11. Yen-Bin Hsu, Chi-Ying F. Huang, Kuan-Ting Lin, Yu-Lun Kuo, Ming-Chin Lan and Ming-Ying Lan. Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma. BioMed Research International 2019: 7457013 (2019)
12. Wei-Hsiang Hsu, Se-Chun Liao, Yau-Jan Chyan, Kai-Wen Huang, Shih-Lan Hsu, Yi-Chen Chen, Ma-Li Siu, Chia-Chuan Chang, Yuh-Shan Chung, Chi-Ying F. Huang*. Graptopetalum paraguayense Inhibits Liver Fibrosis by Blocking TGF-β Signaling In Vivo and In Vitro. International Journal of Molecular Sciences 20(10):2592 (2019)
13. Pei-Chun Wu, Ming-Ji Fann, Tu Thanh Tran, Shu-Cian Chen, Tania Devina, Irene Han-Juo Cheng, Cheng-Chang Lien, Lung-Sen Kao, Shuu-Jiun Wang, Jong-Ling Fuh, Tsai-Teng Tzeng, Chi-Ying Huang, Young-Ji Shiao* and Yu-Hui Wong*. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons. Scientific Reports 9(1):19301 (2019)
14. Se-Chun Liao, Hsiu-Wen Hsu, Kun-Lin Chuang, Zi-Yi Huang, Kuan-Ting Lin, Wei-Hsiang Hsu, Kai-Hsun Chang, Chi-Yin F. Huang*, Chun-Li Su*. Using the Pleiotropic Characteristics of Curcumin to Validate the Potential Application of a Novel Gene Screening Platform. Nutrients 11(6):1397 (2019) (*corresponding author)
15. Jade H.-M. Hsu, Peter M.-H. Chang, Tai-Shan Cheng, Yu-Lun Kuo, Alexander T.-H. Wu, Thu-Ha Tran, Yun-Hsuan Yang, Jing-Ming Chen, Yu-Chen Tsai, Yeh-Shiu Chu, Tse- Hung Huang*, Chi-Ying F. Huang*, and Jin-Mei Lai*. Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer. Cancers 11(7): 1003 (2019) (*corresponding author)
16.  Chi-Shiuan Wu, Shan-Ying Wu, Hsin-Chih Chen, Chien-An Chu, Han-Hsuan Tang, Hsiao-Sheng Liu, Yi-Ren Hong, Chi-Ying F. Huang*, Guan-Cheng Huang*, Chun-Li Su*. Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib. The Journal of Nutritional Biochemistry 74:108227 (2019) (*corresponding author)
17. Hsueh-Ju Lu, Chih-Cheng Hsieh, Chi-Chun Yeh, Yi-Chen Yeh, Chun-Chi Wu, Feng-Sheng Wang, Jin-Mei Lai, Muh-Hwa Yang, Cheng-Hsu Wang, Chi-Ying F. Huang*, and Peter Mu-Hsin*. Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy. Scientific Reports 9(1):12913 (2019) (*corresponding author)
18. Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Hui Wong, Yin-Hsuan Wang, Yun-Ling Lai, Chia-Hua Chou, Chihuei Wang, Joon-Khim Loh, Ann-Shung Lieu, Jiin-Tsuey Cheng, Yu-Te Lin, Pei-Jung Lu, Ming-Ji Fann, Chi-Ying Huang*, Yi-Ren Hong*. GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease. Journal of Clinical Medicine 8(10):1751 (2019) (*corresponding author) 
19. Tse-Hung Huang, Alexander T. H. Wu, Tai-Shan Cheng, Kuan-Ting Lin, Chia-Jou Lai, Hao-Wen Hsieh, Peter Mu-Hsin Chang, Cheng-Wen Wu, Chi-Ying F. Huang*, Kuan-Yu Chen*. In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non–small-cell lung cancer. Journal of Cellular and Molecular Medicine 23(12):8184-8195 (2019) (*corresponding author)
20.  Se-Chun Liao, Wei-Hsiang Hsu, Zi-Yi Huang, Kun-Lin Chuang, Kuan-Ting Lin, Chia-Ling Tseng, Tung-Hu Tsai, Anh-Hoang Dao, Chun-Li Su*, and Chi-Ying F. Huang*. Bioactivity Evaluation of a Novel Formulated Curcumin. Nutrients 11(12):2982 (2019) (*corresponding author)
21. Yen-Bin Hsu, Ming-Chin Lan, Yu-Lun Kuo, Chi-Ying F. Huang*, Ming-Ying Lan*. A preclinical evaluation of thiostrepton, a natural antibiotic, in nasopharyngeal carcinoma. Investigational New Drugs 38(2):264-273 (2020) (*corresponding author).
22. Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Yu-Wen Liu, Juxian Song, Ananth Kumar Kammala, Sravan G. Sreenivasmurthy, Sandeep Malampati, Benjamin Chun-Kit Tong, Karthikeyan Selvarasu, King-Ho CHEUNG, Jiahong Lu, Jieqiong Tan, Chi-Ying F. Huang*, Siva Sundara Kumar Durairajan*, Li Min*. Yuan-Hu Zhi Tong Prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of Alzheimer’s disease. Frontiers in Pharmacology, section Ethnopharmacology 11:584770 (2020) (*corresponding author)
23. Cheng-Yu Tsai, Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Ling Lai, Chia-Chung Hou, Tehseen Javaria, Zi-Yi Huang, Tai-Shan Cheng, Tsung-I Hsu, Jian-Ying Chuang, Aij-Lie Kwan, Tsung-Hsien Chuang, Chi-Ying F. Huang*, Joon-Khim Loh* and Yi-Ren Hong*. NBM-BMX, a HDAC8 inhibitor, overcomes temozolomide resistance in glioblastoma multiforme by downregulating the β- catenin/c-Myc/SOX2 pathway and upregulating p53-mediated MGMT inhibition. Int. J. Mol. Sci. 22:5907 (2021) (*corresponding author)
24. Jia-Ying Chien, Shu-Fang Lin, Yu-Yau Chou, Chi-Ying F. Huang*, and Shun-Ping Huang*. Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy. Antioxidants 10(6):902 (2021) (*corresponding author)
25. Yuan-Chieh Yeh, Bashir Lawal, Michael Hsiao, Tse-Hung Huang*, Chi-Ying F. Huang*. Identification of NSP3 (SH2D3C) as a Prognostic Biomarker of Tumor Progression and Immune Evasion for Lung Cancer and Evaluation of Organosulfur Compounds from Allium sativum L. as Therapeutic Candidates. Biomedicines 9(11):1582 (2021) (*corresponding author)
26. Yan-Xi Chen, Phuong Thu Nguyen Le, Tsai-Teng Tzeng, Thu-Ha Tran, Anh Thuc Nguyen, Irene Han-Juo Cheng, Chi-Ying Huang*, Young-Ji Shiao*, Tsui-Ting Ching*. Graptopetalum paraguayense extract ameliorates proteotoxicity in aging and age-related diseases in model systems. Nutrients 13(12):4317 (2021) (*corresponding author)
27. Yuan-Chieh Yeh, Ly Hien Doan, Zi-Yi Huang, Li-Wei Chu, Tzu-Hau Shi, Ying-Ray Lee, Cheng-Tao Wu, Chao-Hsiung Lin, Shu-Tuan Chiang, Hui-Kang Liu, Tsung-Hsien Chuang, Yueh-Hsin Ping*, Hsiao-Sheng Liu* and Chi-Ying F. Huang*. Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) suppress SARS-CoV-2 entry and COVID-19 related cytokine storm in vitro. Frontiers in Pharmacology 12:765553 (2022)
28. Thu Thi Kim Ninh, Tuan Hiep Tran, Chi Ying F. Huang* and Chien Ngoc Nguyen*. Application of computational screening tools and nanotechnology for enhanced drug synergism in cancer therapy. Current Drug Delivery (2022) (*corresponding author) DOI: 10.2174/1567201819666220426092538
29. Ly Hien Doan, Li-Wei Chu, Zi-Yi Huang, Anh Thuc Nguyen, Chia-Yin Lee, Chien-Ling Huang, Yu-Fen Chang, Wen-Yu Hsieh, Trang Thi Huyen Nguyen, Chao-Hsiung Lin, Chun-Li Su, Tsung-Hsien Chuang, Jin-Mei Lai, Feng-Sheng Wang, Chia-Jui Yang, Hui-Kang Liu*, Yueh-Hsin Ping*, Chi-Ying F. Huang*. Virofree, an herbal medicine-based formula, interrupts the viral infection of Delta and Omicron variants of SARS-CoV-2. Frontiers in Pharmacology 13:905197 (2022) 
30. Li-Jie Li, Chien-Hsiu Li, Peter Mu-Hsin Chang, Tsung-Ching Lai, Chen-Yin Yong, Sheng-Wei Feng, Michael Hsiao, Wei-Min Chang* and Chi-Ying F. Huang*. Dehydroepiandrosterone (DHEA) Sensitizes Irinotecan to Suppress Head and Neck Cancer Stem-like Cells by Downregulation of WNT Signaling. Frontiers in Oncology 12:775541 
31. Yueh-Shih Chang, Yi-Cheng Lan, Ya-Jyun Chen, Jen-Seng Huang, Chia-Ning Yang*, Chi-Ying F. Huang* and Kun-Yun Yeh* A Novel Phenotype of the Factor 5 Gene Mutation (Homozygote Met1736Val and Heterozygote Asp68His) Is Associated With Moderate Factor V Deficiency. Frontiers in Medicine 9:870269